The Academic Health Service Complex of the Eastern Cape consists of health facilities at all levels of health care (level 1, level 2 and level 3). The functions of the AHSC include teaching and learning, research, service and community engagement. WSU-Nelson Mandela Academic Hospital serves as the epicentre with other Provincial Hospitals, District Hospitals, Community Health Centres and Health Resource Centres being integral parts of the Teaching Platform.

In addition to being a centre for teaching of both undergraduate and postgraduate students, NMAH is also a referral hospital for Highly Specialised Hospital Care, serving 2,6 million people. The foundation stone was laid by the former State President of South Africa, Dr Nelson Mandela after whom the Hospital is named. The Sod- Turning Ceremony to commence construction was inaugurated by the then State President of South Africa, Mr Thabo Mbeki.